1,373 research outputs found
Capitalization of Capital Gains Taxes: Evidence from Stock Price Reactions to the 1997 Rate Reduction
We empirically document that stock prices moved inversely with dividend yields during the May, 1997 week, when the White House and Congress agreed on a budget accord that included a reduction in the capital gains tax rate. The share prices of firms not currently paying dividends increased approximately 6 percentage points more over a five-day window than the share prices of other firms. Among firms paying dividends, the change in share prices was decreasing in dividend yields. The results are consistent with at least two related explanations. First, to the extent a stock's returns are expected to be taxed as capital gains, a reduction in the expected capital gains tax rate enhances the attractiveness of the investment to investors. Second, to the extent a firm's stock is held by shareholders subject to the capital gains tax, a reduction in the expected capital gains tax rate increases its market value. The findings present evidence consistent with neither a sell-off of appreciated securities following the rate reduction nor a reduction in the compensation for capital gains taxes that selling shareholders demand from buyers. The upward price pressure around the accord dominated any downward price pressure imposed by these factors.
A Radio Polarimetric Study of the Galactic Center Threads
Multi-frequency, polarimetric VLA observations of the non-thermal filaments
(NTF's), G0.08+0.15, and G359.96+0.09, also known as the Northern and Southern
Threads are presented at 20, 6, 3.6 and 2 cm, with high enough spatial
resolution to be resolved for the first time at 6 and 3.6 cm. The 20 cm image
reveals a wealth of new detail in the radio sources lying within the inner 60
pc of the Galaxy. The Southern Thread has a prominent split along its length,
similar to splitting at the ends of previously studied NTF's. With resolutions
as fine as 2'', the 3.6 and 6 cm images reveal a high degree of continuity and
little substructure internal to the filament. The spectral index of the
Northern Thread has been determined over a broad range of frequencies. Its flux
density falls with frequency, alpha=-0.5 between 90 and 6 cm, and becomes much
steeper (alpha=-2.0) between 6 and 2 cm. The spectral index does not vary
significantly along the length of the Northern Thread, which implies either
that the diffusion timescale for the emitting electrons is less than their
synchrotron lifetime, or that the emitting electrons are reaccelerated
continuously at multiple positions along the filament. Because of the lack of
spectral index variation, we have not located the source of relativistic
electrons. Polarization observations at 6 and 3.6 cm confirm the non-thermal
nature of the emission from the Northern Thread. The fractional polarization in
the Northern Thread reaches 70% in some regions, although the polarized
emission is patchy. Large rotation measures (RM > 2000 rad/m2) have been
observed with irregular variations across the filament.The intrinsic magnetic
field in the Northern Thread is predominantly aligned along its long axis.Comment: 19 pages, incl. 24 figs; to appear in the Astrophysical Journa
Two-dimensional Hubbard-Holstein bipolaron
We present a diagrammatic Monte Carlo study of the properties of the
Hubbard-Holstein bipolaron on a two-dimensional square lattice. With a small
Coulomb repulsion, U, and with increasing electron-phonon interaction, and when
reaching a value about two times smaller than the one corresponding to the
transition of light polaron to heavy polaron, the system suffers a sharp
transition from a state formed by two weakly bound light polarons to a heavy,
strongly bound on-site bipolaron. Aside from this rather conventional bipolaron
a new bipolaron state is found for large U at intermediate and large
electron-phonon coupling, corresponding to two polarons bound on
nearest-neighbor sites. We discuss both the properties of the different
bipolaron states and the transition from one state to another. We present a
phase diagram in parameter space defined by the electron-phonon coupling and U.
Our numerical method does not use any artificial approximation and can be
easily modified to other bipolaron models with longer range electron-phonon
and/or electron-electron interaction.Comment: 14 pages, 12 figure
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the roughly one
hundred components, which are involved in protein import and protein folding or assembly, two
components stand out: The Sec61 complex and BiP. The Sec61 complex in the ER membrane represents
the major entry point for precursor polypeptides into the membrane or lumen of the ER and provides
a conduit for Ca2+ ions from the ER lumen to the cytosol. The second component, the Hsp70-type
molecular chaperone immunoglobulin heavy chain binding protein, short BiP, plays central roles
in protein folding and assembly (hence its name), protein import, cellular Ca2+ homeostasis, and
various intracellular signal transduction pathways. For the purpose of this review, we focus on
these two components, their relevant allosteric effectors and on the question of how their respective
functional cycles are linked in order to reconcile the apparently contradictory features of the ER
membrane, selective permeability for precursor polypeptides, and impermeability for Ca2+. The
key issues are that the Sec61 complex exists in two conformations: An open and a closed state
that are in a dynamic equilibrium with each other, and that BiP contributes to its gating in both
directions in cooperation with different co-chaperones. While the open Sec61 complex forms an
aqueous polypeptide-conducting- and transiently Ca2+-permeable channel, the closed complex
is impermeable even to Ca2+. Therefore, we discuss the human hereditary and tumor diseases
that are linked to Sec61 channel gating, termed Sec61-channelopathies, as disturbances of selective
polypeptide-impermeability and/or aberrant Ca2+-permeability
Noise-free scattering of the quantized electromagnetic field from a dispersive linear dielectric
We study the scattering of the quantized electromagnetic field from a linear,
dispersive dielectric using the scattering formalism for quantum fields. The
medium is modeled as a collection of harmonic oscillators with a number of
distinct resonance frequencies. This model corresponds to the Sellmeir
expansion, which is widely used to describe experimental data for real
dispersive media. The integral equation for the interpolating field in terms of
the in field is solved and the solution used to find the out field. The
relation between the in and out creation and annihilation operators is found
which allows one to calculate the S-matrix for this system. In this model, we
find that there are absorption bands, but the input-output relations are
completely unitary. No additional quantum noise terms are required.Comment: Revtex, submitted to Physical Review
Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.Fil: Larcade, Ramon. No especifíca;Fil: DeShea, Lise. Oklahoma State University; Estados UnidosFil: Lang, Gillian A.. Oklahoma State University; Estados UnidosFil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Beasley, William H.. Oklahoma State University; Estados UnidosFil: Tipple, Trent E.. Oklahoma State University; Estados UnidosFil: Vain, Néstor Eduardo. No especifíca;Fil: Prudent, Luis. No especifíca;Fil: Lang, Mark L.. Oklahoma State University; Estados UnidosFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Ofman, Gaston. Fundación para la Investigación en Infectología Infantil; Argentin
On the stability of periodic orbits in delay equations with large delay
We prove a necessary and sufficient criterion for the exponential stability
of periodic solutions of delay differential equations with large delay. We show
that for sufficiently large delay the Floquet spectrum near criticality is
characterized by a set of curves, which we call asymptotic continuous spectrum,
that is independent on the delay.Comment: postprint versio
Criteria for the diagnosis of corticobasal degeneration
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases from published reports and brain banks. Combined with consensus, 4 CBD phenotypes emerged: corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and progressive supranuclear palsy syndrome (PSPS). Clinical features of CBD cases were extracted from descriptions of 209 brain bank and published patients, providing a comprehensive description of CBD and correcting common misconceptions. Clinical CBD phenotypes and features were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies. Probable CBD criteria require insidious onset and gradual progression for at least 1 year, age at onset ≥50 years, no similar family history or known tau mutations, and a clinical phenotype of probable CBS or either FBS or naPPA with at least 1 CBS feature. The possible CBD category uses similar criteria but has no restrictions on age or family history, allows tau mutations, permits less rigorous phenotype fulfillment, and includes a PSPS phenotype. Future validation and refinement of the proposed criteria are needed
A comparison of RNA amplification techniques at sub-nanogram input concentration
<p>Abstract</p> <p>Background</p> <p>Gene expression profiling of small numbers of cells requires high-fidelity amplification of sub-nanogram amounts of RNA. Several methods for RNA amplification are available; however, there has been little consideration of the accuracy of these methods when working with very low-input quantities of RNA as is often required with rare clinical samples. Starting with 250 picograms-3.3 nanograms of total RNA, we compared two linear amplification methods 1) modified T7 and 2) Arcturus RiboAmp HS and a logarithmic amplification, 3) Balanced PCR. Microarray data from each amplification method were validated against quantitative real-time PCR (QPCR) for 37 genes.</p> <p>Results</p> <p>For high intensity spots, mean Pearson correlations were quite acceptable for both total RNA and low-input quantities amplified with each of the 3 methods. Microarray filtering and data processing has an important effect on the correlation coefficient results generated by each method. Arrays derived from total RNA had higher Pearson's correlations than did arrays derived from amplified RNA when considering the entire unprocessed dataset, however, when considering a gene set of high signal intensity, the amplified arrays had superior correlation coefficients than did the total RNA arrays.</p> <p>Conclusion</p> <p>Gene expression arrays can be obtained with sub-nanogram input of total RNA. High intensity spots showed better correlation on array-array analysis than did unfiltered data, however, QPCR validated the accuracy of gene expression array profiling from low-input quantities of RNA with all 3 amplification techniques. RNA amplification and expression analysis at the sub-nanogram input level is both feasible and accurate if data processing is used to focus attention to high intensity genes for microarrays or if QPCR is used as a gold standard for validation.</p
Dark resonances for ground state transfer of molecular quantum gases
One possible way to produce ultracold, high-phase-space-density quantum gases
of molecules in the rovibronic ground state is given by molecule association
from quantum-degenerate atomic gases on a Feshbach resonance and subsequent
coherent optical multi-photon transfer into the rovibronic ground state. In
ultracold samples of Cs_2 molecules, we observe two-photon dark resonances that
connect the intermediate rovibrational level |v=73,J=2> with the rovibrational
ground state |v=0,J=0> of the singlet ground state potential.
For precise dark resonance spectroscopy we exploit the fact that it is possible
to efficiently populate the level |v=73,J=2> by two-photon transfer from the
dissociation threshold with the stimulated Raman adiabatic passage (STIRAP)
technique. We find that at least one of the two-photon resonances is
sufficiently strong to allow future implementation of coherent STIRAP transfer
of a molecular quantum gas to the rovibrational ground state |v=0,J=0>.Comment: 7 pages, 4 figure
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